Table 3 Role of sEVs cargo in chemoresistance of GC
From: The role and application of small extracellular vesicles in gastric cancer
| Drug | Contents | Type | Function | Ref. |
|---|---|---|---|---|
| Cisplatin | RPS3 | protein | Promote the chemoresistance of cisplatin-sensitive cells | [98] |
| miR-21 | miRNA | Tumour-associated macrophages derived sEVs-miR-21 confer cisplatin resistance in GC | [99] | |
| anti-miR-214 | miRNA | Reverse the resistance to cisplatin in GC | [52] | |
| miR-522 | miRNA | Inhibit ferroptosis in cancer cells by targeting ALOX15 and blocking lipid-ROS accumulation | [100] | |
| miR-500a-3p | miRNA | Could be a potential modality for the prediction and treatment of GC with chemoresistance | [101] | |
| HOTTIP | lncRNA | Contribute to cisplatin resistance in GC cells by regulating miR-218/HMGA1 axis | [102] | |
| circ-0000260 | circRNA | Contribute to cisplatin resistance by upregulating MMP11 via targeting miR-129-5p. | [103] | |
| circ-PVT1 | circRNA | Contribute to cisplatin resistance via miR-30a-5p/YAP1 axis. | [104] | |
| Oxaliplatin | circ-0032821 | circRNA | Contribute to oxaliplatin resistance by regulating SOX9 via miR-515-5p | [105] |
| 5-FU | TFAP2E | protein | Hypermethylation of TFAP2E resulted in 5-FU chemoresistance in GC cells | [106] |
| Doxorubicin | miR-501 | miRNA | Resistance to doxorubicin is possibly achieved by sEVs-miR-501-induced downregulation of BLID, subsequent inactivation of caspase-9/− 3 and phosphorylation of Akt. | [107] |
| miR-223 | miRNA | Promote doxorubicin resistance in GC cells by inhibiting FBXW7. | [108] | |
| Vincristine | CLIC1 | protein | Induce the development of resistance to vincristine in vitro, which might relate to up-regulated P-gp and Bcl-2. | [109] |
| Paclitaxel | miR-155-5p | miRNA | Induce EMT and chemo-resistant phenotypes from paclitaxel-resistant GC cells to the sensitive cells, which may be mediated by GATA3 and TP53INP1 suppression. | [110] |