The role and application of small extracellular vesicles in gastric cancer

Table 2 Role of sEVs cargo in angiogenesis and metastasis of GC

Type	Contents	Donor cells	Recipient cells	Function	Ref.
protein	TRIM3	Overexpressed MGC-803 and SGC-7901	MGC-803 and SGC-7901	Suppress GC metastasis	[56]
protein	YB-1	SGC-7901	HUVECs	Promote angiogenesis	[76]
protein	EGFR	SGC-7901	Liver cells	Promote GC liver metastasis	[77]
protein	Wnt5a	LNM-derived GC cells	BM-MSCs	maintaining tumour-promoting phenotype and function	[78]
miRNA	miR-130a	SGC-7901	HUVECs	Promote angiogenesis and tumour growth	[79]
miRNA	miR-135b	SGC-7901	HUVECs	Promote angiogenesis	[80]
miRNA	miR-155	SGC-7901	HUVECs	Promote growth, metastasis, and tube formation of vascular cells	[81, 82]
miRNA	miR-23a	HGC-27	HUVECs	Promote angiogenesis	[83]
miRNA	miR-6785-5p	HUVECs	MGC-803 and SGC-7901	Suppress angiogenesis and metastasis	[84]
miRNA	miR-196a-1	GSU and N-87	GSU and N-87	Promote GC cell invasion and metastasis	[85]
miRNA	GKN1	HFE-145	AGS and MKN1	Suppress migration and invasion of GC cells by inhibiting epithelial-mesenchymal transition.	[71]
miRNA	miR-29	Peritoneal fluid	/	Suppress growth of disseminated peritoneal tumour cells	[86]
miRNA	miR-21-5p	MGC-803, MKN-45, HGC- 27, and SGC-7901	PMC and HMrSV5	Induce MMT and promote tumour peritoneal metastasis	[87]
miRNA	miR-423-5p	Overexpressed SGC-7901 and HGC-27	SGC-7901 and HGC-27	Promote GC metastasis	[61]
miRNA	miR-301a-3p	Hypoxia MGC803	MGC803 and MKN45	Promote GC metastasis	[63]
lncRNA	PCGEM1	HGC	NGC	Promote invasive and metastasis	[88]
ncRNA	X26nt	MGC-803	HUVECs	Increases angiogenesis and vascular permeability	[89]
circRNA	circ-RanGAP1	HGC-27 and AGS	HGC-27 and AGS	Promote GC invasion and metastasis	[90]

ISSN: 1476-4598